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Science and research

How we think about evidence

What we will claim, what we will not, and where the evidence behind each pillar actually comes from.

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Our standard

We cite public, peer reviewed literature about underlying physiology. We do not run studies, we have no outcome data of our own, and we are not going to imply otherwise by dressing up a chart. When you see a figure on this site it is labelled illustrative, because it is.

What good evidence looks like here

  • Population evidence is not a personal prediction. A large cohort study tells you about averages across many people. It does not tell you what will happen to you.
  • Association is not causation. Much of the longevity literature is observational. It is genuinely useful and it is not proof that changing the marker changes the outcome.
  • Surrogate markers are a means, not the goal. Moving a number is only worth something if the number tracks something that matters.
  • Absence of evidence is common. Plenty of popular interventions have little good human data. The honest answer is often "we do not know yet".

Where we are deliberately quiet

There are areas of this field with enthusiastic marketing and thin evidence. We would rather say nothing than repeat a claim we cannot support, so you will find some popular topics absent from this site. That is a choice, not an oversight.

What we cannot tell you. Nothing here is advice for your situation. The literature below describes physiology in populations. What any of it means for you is a conversation with a clinician who has actually evaluated you.

References

  1. Sniderman AD et al. "Apolipoprotein B Particles and Cardiovascular Disease: A Narrative Review." JAMA Cardiology, 2019.
  2. Mandsager K et al. "Association of Cardiorespiratory Fitness With Long-term Mortality Among Adults Undergoing Exercise Treadmill Testing." JAMA Network Open, 2018.
  3. Cappuccio FP et al. "Sleep duration predicts cardiovascular outcomes: a systematic review and meta-analysis of prospective studies." European Heart Journal, 2011.
  4. Knowler WC et al. "Reduction in the Incidence of Type 2 Diabetes with Lifestyle Intervention or Metformin." New England Journal of Medicine, 2002.
  5. Leproult R, Van Cauter E. "Effect of 1 week of sleep restriction on testosterone levels in young healthy men." JAMA, 2011.
  6. Cruz-Jentoft AJ et al. "Sarcopenia: revised European consensus on definition and diagnosis." Age and Ageing, 2019.

These are public, peer reviewed sources about the underlying physiology. They are not studies of SiriusRX and they do not describe results anyone should expect from us.

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